DOWNLOAD ~ Use and Abuse of the Controlled Clinical Trial (Nyu Hospital for Joint Diseases Clinical Research Methodology Course) (Report) by Bulletin of the NYU Hospital for Joint Diseases ~ Book PDF Kindle ePub Free
eBook details
- Title: Use and Abuse of the Controlled Clinical Trial (Nyu Hospital for Joint Diseases Clinical Research Methodology Course) (Report)
- Author : Bulletin of the NYU Hospital for Joint Diseases
- Release Date : January 01, 2007
- Genre: Health & Fitness,Books,Health, Mind & Body,
- Pages : * pages
- Size : 219 KB
Description
There has been much discussion of late that confidence in medicine is being eroded. No less an authority than Elias A. Zerhouni, M.D., Director of the National Institutes of Health (NIH), Bethesda, Maryland, has recently said, "Forty percent of science news relates to health and medicine," noting as well, "and we are seeing a gradual erosion of public trust." (1) The main thrust of this discussion is the ever profiteering drug industry, the ever loosening professional standards of the physicians, and the standing and expectations from the state health authorities, i.e., the Federal Drug Administration (FDA), among others. The most common scenario is the new "blockbuster" drug, introduced initially as the breakthrough. After enjoying the market for several years, the drug turns out to be not much better and, in fact, is observed to be more toxic than what had been available when it was first launched. In all this discussion, with the inevitable "saucy" representation in the news media, I think there is one important "paragraph" that has been forgotten, the highlighting of which is my particular aim with this communication. Although some would disagree, (2) the randomized controlled trial (RCT) is the appropriate golden measure to scientifically judge the claimed efficacy of a new remedy. It should come as no surprise, with some historical review, that the first RCT designed to test the efficacy of streptomycin in treating tuberculosis was conducted shortly after World War II in 1948. (2) During the times that led to the first RCT, scientific research, in general, underwent an important change in methodology. The inductive reasoning that had dominated Western science, practically since the Renaissance, gave way to deductive reasoning, with its "falsifiable hypotheses." These were the times of, among others, Einstein, Medawar, and Feynman. The dominant philosopher of this new era was, of course, Karl Popper, who, in brief, argued that the main activity of the scientist was to falsify a hypothesis, and it was only after the failure of a genuine effort at falsification that a scientific truth could be established. (3)
 (Report) by Bulletin of the NYU Hospital for Joint Diseases ~ Book PDF Kindle ePub Free){kind=link}
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